Association between genetic polymorphisms of antioxidant enzyme genes and susceptibility to hepatocellular carcinoma: a meta-analysis

This study was to analysis the correlation between genetic polymorphisms in antioxidant enzyme genes and the susceptibility factors to hepatocellular carcinoma (HCC) using meta analysis. Electronic searches were conducted in Pubmed, Embase and Cochrane library. Retrieval keywords included antioxidant enzyme, superoxide dismutases, catalase, glutathione peroxidase, and hepatocellular carcinoma. Retrieval strategy was: ((antioxidant enzyme) OR (superoxide dismutases) OR catalase OR (glutathione peroxidase)) AND (hepatocellular carcinoma) OR HCC) AND polymorphism (OR gene OR based OR Allele * OR Genotyp * OR susceptibility). Selection criteria, data extraction and quality evaluation, and statistical analysis of articles were performed. For MnSOD, there were 2351 cases, including 1048 patients and 1303 control. For CAT, there were 2166 cases, including 987 patients and 1179 control. For GPX1, there were 1437 cases, including 614 patients and 823 control. The recessive model (Ala/Ala vs. Val/Val/Val + Ala) of MnSOD was associated with the risk of HCC (OR = 1.49, [95% CI: 1.04, 2.15]) (P = 0.03). MnSOD (allele model [Ala vs. Val], codominant model [Ala/Ala vs. Val/Val], codominant model [Val/Ala vs. Val/Val], and dominant model [Ala/Ala + Val/Ala vs. Val/Val]), CAT (262 C > T) (allele model [T vs. C], codominant model [TT vs. CC], codominant model [CT vs. CC], dominant model [TT + CT vs. CC], and recessive model [TT vs. CT + CT]), and GPX1 (Pro198Leu) (allele model [Leu vs. Pro], codominant model [Leu/Leu vs. Pro/Pro], codominant model [Leu/ Pro vs. Pro/Pro], dominant model [Leu/Leu + Leu/Pro vs. Pro/Pro] and recessive model [Leu/Leu vs. Pro/Pro + Leu/Pro]) were no significant correlation with the incidence of HCC (P > 0.05). The implicit model (Ala/Ala vs. Val/ Val/Val + Ala) of MnSOD was significantly correlated with the incidence of HCC. However, CAT (262 C > T) and GPX1 (Pro198Leu) were no significant correlation with the incidence of HCC.